Host- Microbe interactions
The host-pathogen interface presents interesting cellular changes observable under electron microscope - happening to the pathogens for enhanced virulence, including formation of surface 'invasosomal' periplasmic organelles and exocytosis of bacterial outer membrane vesicles by gram-negative pathogens (e.g., Salmonella). Host cell cytoskeletal re-organisational changes e.g., ruffle formation, altered phagocytosis, etc. also the take place as a prelude to microbial invasion
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